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KMID : 1007320070130020114
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Journal of the Korean Society of Menopause
2007 Volume.13 No. 2 p.114 ~ p.122
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Effect of Hormone Replacement Therapy on Bone Mineral Density in Korean Postmenopausal Women over the Age of 60
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Kim Woo-Sun
Yoon Byung-Koo
Kim Ji-Young
Choi Doo-Seok
Lee Jae-Ho
Kim Joo-Han
Kim Kwang-Won
Min Yong-Ki
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Abstract
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Objectives: Hormone replacement therapy (HRT) prevents bone loss in postmenopausal women. We studied the effect of HRT on bone mineral density (BMD) in Korean women over the age of 60.
Methods: We measured BMD at the lumbar spine and femur neck by dual-energy X-ray absorptiometry at baseline, 6, 12, and 24 months after HRT in 86 Korean postmenopausal women (age over 60, n=28; below 60, n=58). Women were given 0.625 mg of conjugated estrogen or the equivalent for 25 days or more each month. Women with uterus received continuous or sequential progesterone additionally.
Results: HRT in women over the age of 60 was equally effective as in younger women in increasing BMD. The percentage changes, especially of lumbar BMD at 6 months after HRT were greater in the older women (3.6±3.7% vs. 5.7±7.3%, P＜0.05). There was no difference in biochemical markers of bone turnover (serum osteocalcin, urine deoxypyridinoline) at baseline between two groups, they decreased significantly in both groups at 3 months after HRT.
Conclusion: Data shows that postmenopausal women over the age of 60 tend to respond to HRT with similar increments in BMD compared to those in women below the age of 60. Moreover, the increment in lumbar BMD of women over the age of 60 is greater than that of the women below the age of 60.
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KEYWORD
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Hormone replacement therapy, HRT, Postmenopausal women, Osteoporosis, Bone mineral density, BMD
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